JW Pharma unveils trial result for target anticancer treatment

Lee Han-soo  Published 2017.12.11  16:55  Updated 2017.12.11 16:55


JW Pharmaceuticals said Monday that it has presented phase 1a/1b clinical trial results for CWP291, a target anticancer treatment that uses Wnt pathway, at the American Society of Hematology.

CWP291 is a first-in-class target anticancer drug that inhibits the growth of cancer cells and the mechanism of Wnt/b-catenin, a signaling substance involved in cancer stem cells. The drug also has important biomarkers, such as increasing C/EBP homologous proteins which is a major factor of apoptosis of cancer cells.

The company launched phase 1a clinical trials for CWP291 on 11 patients with relapsed or refractory multiple myeloma in the U.S. and Korea in 2015 while launching phase 1b clinical trials that use CWP291 in combination with lenalidomide and dexamethasone on eight patients last year.

As a result, 45 percent of the patients maintained a stable disease state with no progression in phase 1a trials, while 63 percent of phase 1b trial patients saw a decrease in M-protein, an abnormal protein produced from the malignant plasma cells, from their serum and urine. The company has also confirmed safety for CWP291 and is confirming maximum tolerated dosage in both clinical trials.

JW Pharmaceuticals expects CWP291 to become a new treatment that will replace standard therapies, as it confirmed efficacy in treating patients who have failed treatment even though they received bone marrow transplantation or single and combined chemotherapy with drugs such as bortezomib, dexamethasone, lenalidomide, and pomalidomide.

“The recent presentation at the American Society of Hematology has confirmed the efficacy of the Wnt/b-catenin inhibitor CWP291 in combination therapy, which has recently become a major trend in the anticancer drug market,” a company official said. “The company plans to increase the value of CWP291 as a global new drug by securing additional data on efficacy while increasing its dosage in various stages.”

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